Welcome to the Koleske Lab

Welcome to the Koleske Lab

Our long-term goal is to understand the molecular mechanisms by which growth factor and adhesion receptors regulate cell shape, structural stability, and movement. We have identified a set of adhesion and growth factor receptors, kinases, scaffolding proteins, and cytoskeletal modulators as key regulators of these processes. We strive to define the biochemical mechanisms by which extracellular cues direct this group of proteins to control cytoskeletal structure and dynamics and how this impacts cell structure, stability, and movement. We are applying the principles uncovered and strategies we have developed to understand how cancer cells escape the tumor and invade surrounding tissue and how fibroblasts migrate on adhesive substrates. In major new initiatives, we will discover how neuronal circuits maintain stability in the adolescent mouse brain, and work to understand how stress and psychostimulant abuse disrupt neuronal structure and connectivity. We hope to translate our discoveries into improved therapies to treat breast cancer, neurodevelopmental disorders, and neurodegenerative disease.

News

March 26, 2021
Congratulations to Daisy Duan who was recently awarded the NSF Graduate Research Fellowship! Daisy’s thesis project focuses on elucidating the mechanism by which the...
January 25, 2021
The Koleske Lab kicked off the year 2021 with a special new lab member: Dr. Rob Niescier! Rob Niescier earned his PhD from the Ulsan National Institute of Science and...
January 13, 2021
Both Daisy Duan and Melissa Carrizales have successfully passed their MB&B oral qualifying exams on August 19th, 2020 and November 17th, 2020, respectively. Now en route...